摘要
应用免疫组化ABC技术对60例早期胃癌胃粘膜肠化和异型增生中ConA、DBA、PHA、PNA和WGA结合糖基及CEA的研究发现,各糖基和CEA的分布与正常胃粘膜不同。部分糖基和CEA在癌旁肠化和异型增生的阳性率明显高于切缘和慢性胃炎。凝集素标记的肠化新分型显示肠型癌和弥漫型癌胃粘膜肠化主要为结肠型(ConA+PNA-)和混合型(ConA+PNA+),部分弥漫型癌起源可能与结肠型肠化有关。
Carbohydrate residues marked by five biotinylatedlectins (Con A, DBA, PHA, PNA, WGA) and carcinoembryonic antigen (CEA) in intestinal metaplasia and dysplasia adjacent to early gastric carcinoma (EGC) were studied immunohistochemically using ABC technique. The results were as following.The distribution of carbohydrate residues in intestinal metaplasia and dysplasia was different from normal gastric mucosa. The ratio of positivity for DBA and CEA was significantly higher in mucosa adjacent to gastric carcinoma than that in intestinal metaplasia in chronic gastritis and gastric resection margins. The new classification of intestinal metaplasia based on lectin binding demonstrated that the metaplasia was predominantly metaplasia of colonic (ConA + PNA-) and mixed types (ConA +PNA + ) in Carcinoma free gastric mucosa of either intestinal or diffuse carcionma. Some of the diffuse gastric carcinomas may originate from the intestinal meiaplasia.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1992年第3期184-186,共3页
Medical Journal of Chinese People's Liberation Army
关键词
胃粘膜
肠上皮化生
糖基
胃肿瘤
Gastric mucosa
Intestinal metaplasia
Dysplasia
Lectin
Carbohydrate residuess
