摘要
临床上乙型肝炎病毒(HBV)感染者中,可合并丁型肝炎病毒(HDV)感染,其临床表现和病理变化轻重悬殊可很大,血清HDAg、抗HD和肝HDAg的检出结果可不一致,采用多项检测指标,可提高HDV感染的检出率。HDV抗原血症除见于急性肝炎外,在各类慢性及重型肝炎中亦占有较大比例,合并有HDV感染者之预后似较差,病死率为32.29％,但也有症状轻微的病例。HDV和原发性肝细胞癌(HCC)的关系有待探讨。15例HDV感染者未检出HBsAg,可能因效价低于目前的检测水平。
Clinical manifestations of 98 patients with HDV/HBV infections discovered between 1984 to 1989 were reported. The diagnosis was confirmed by serological and/or histopatholo-gical examinations. Results: (1) HDV infection coexisted in various clinical categories of HBV infection. Both clinical manifestations and pathological changes may be mild or severe. (2) Results of anti-HD test may not concur with that of HDAg in both the serum and the liver tissue. A higher detect rate could be obtained by using several methods. HDV antigenemia was often present in chronic and fulminant hepatitis of various types besides acute hepatitis, and antigenemia persisted for a longer period. (3)With a mortality rate of 31% (30/96, excluding HCC), the prognosis of HDV/HBV infections seemed to be poor, but there were some mild cases. This was not completely consistent with the hypothesis that HDV might directly injure the hepatocytes. (4)The relationship between HDV and the occurrence of HCC needs further research. Two patients in this group and another case of CAH with anti-HD positive developed HCC 2 years later. (5)HBs-Ag was undetectable in 15 patients, including 5 of AH, 5 CAH, and 5 FH. In these patients, HBV infection might have terminated so that HBsAg titers were too low to be detected.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1992年第1期16-19,共4页
Medical Journal of Chinese People's Liberation Army
关键词
合并感染
丁型肝炎
乙型肝炎
HDV/HBV infection
Hepatitis D
Hepatitis B
