摘要
以家兔皮下注射50％甘油液所致肾功能衰竭为动物模型,利用活体微球示踪技术,透射和扫描电镜观察以及形态计量等方法,探讨了家兔甘油性肾功能衰竭时肾脏微循环变化规律。结果表明,家兔甘油性肾功能衰竭时肾脏微循环变化显著,且与肾功能变化一致。肾功能衰竭早期,肾脏微循环变化是功能性的,注甘油24h后出现明显的微血管结构改变。提示防治急性肾功能衰竭时,改善肾微循环的药物应尽早使用。
This paper reports a study of renal microcirculation in rabbits with glycerol-induced acute renal failure by using the microsphere technique, transmission and scanning electron-microscopy as well as morphemetry. In the initial phase of acute renal failure, there was microcir-culatory ischemia, and the changes were parallel with functional changes following glycerol injection, the renal microcirculation showed marked structureal changes. The results indicated that renal microcirculation should be given early.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1992年第1期36-38,共3页
Medical Journal of Chinese People's Liberation Army
关键词
肾衰竭
微循环
发病机制
Renal failure
Renal microcirculation
Pathogenesis
Rabbit
