摘要
目的 :探讨系统性硬化病 (systemicsclerosis ,SSc)的临床表现 ,提高对SSc的认识。方法 :对 6 8例SSc患者的临床和实验室资料进行回顾性分析。结果 :男女之比为 1∶5 .8,平均发病年龄 37.13± 14 .6 1岁 ;所有患者均有不同程度的皮肤改变 ,雷诺现象 5 3例 (77.94 % ) ,内脏器官受累 4 6例 (6 7.65 % ) ;γ球蛋白升高占 87.2 3% (4 1/ 4 7) ,ANA阳性率 5 9.0 2 % (36 / 6 1) ;与局限型组比较 ,弥漫型组雷诺现象发生较少 (P =0 .0 17) ,而出现关节畸形、内脏受损、白细胞增多及血沉增快者较多 (均P <0 .0 5 ) ;抗Scl- 70阳性率 14 .5 8% (7/ 4 8)且只见于弥漫型组 ,抗RNP阳性率 14 .5 8% (7/ 4 8)且只见于有雷诺现象患者 ;6例死亡者均为弥漫型 ,均死于心、肺、肾等合并症。结论 :SSc常累及多个系统器官 ,并存在多种免疫学异常 ;弥漫型SSc内脏受累较多、较重 ,预后差 ;早期诊治是改善SSc预后的关键。
Objective: To explore the clinical and immunological features of systemic sclerosis (SSc). Methods: The clinical and laboratory data of 68 patients with SSc were analyzed retrospectively. Results: There were 10 male and 58 female(1: 5.8) in this study with mean onset age of (37.13±14.61) years. There were skin damages of different degrees in all patients. Raynaud's phenomenon were presents in 53patients (77.94%), and internal organ involvement in 46 patients (67.65%). The positive rates of elevated ESR, elevated γ-globulin, ANA were 65.08%(41/63), 87.23%(41/47) and 59.02%(36/61), respectively. Compared with the limit SSc group, the cases of Raynaud's phenomenon were less, and the cases of joint malformation, internal organ involvement, leukocytosis and elevated ESR were more in diffuse SSc group (all P<0.05). Anti-Scl-70 were only found in diffuse SSc, and Anti-RNP were only found in cases with Raynaud's phenomenon. All 6 died patients were diffuse SSc. Conclusion: The patients of SSc present several systemic involvements and immunological abnormalities. The diffuse SSc may be more internal organ involvements, more severe, more progressive and poor prognosis. Early diagnosis and treatment was the key point for the prognosis improvement of SSc.
出处
《河北医学》
CAS
2003年第6期508-512,共5页
Hebei Medicine
