摘要
离体豚鼠心室肌模拟“缺血”和再灌注的细胞电生理实验表明:(1)迟后除极电位(DAD)在心肌“缺血”时的发生率仅为16.7%,再灌注时增加到50%。如“缺血”台氏液中加入异丙肾素或增加钙含量,对缺血时的DAD 发生率无影响,再灌注时则分别增加到72.3%和57.1%,并见DAD 引发的持续触发活性;(2)早后除极电位(EAD)在心肌“缺血”时的发生率为8.3%,再灌注时为16.7%,且不受“缺血”台氏液中异丙肾素或高钙的影响,均未引发触发活性。
Cellular Electrophy Siologic experiment of simulated ischemia and reperfusionischemia of isolated guinea pig ventricular muscles was carried out.The result showedthat:(1)incidence of delayed afterdepolarizations(DAD)was 16.7% during simulatedcardiac ischemia and 50% during reperfusion,When ischemic Tyrode solution containing isoproterenol or high Ca^++ level,the incidence of DAD did not change during simulatedischemia,but it increased to 72.3% and 57.1% respectively during reperfusion.Sustainedtriggered aclivity induced by DAD was also observed during reperfusion;(2)incidence ofearly afterdepolarizations(EAD)was 8.3% during simulated cardiac ischemia and 16.7%during reperfusion.The induction of EAD was not influenced by isoproterenol or highCa^++ level containing in ischemic Tyrode solution.Triggered activity induced by EADwas not observed in this experiment.
出处
《江苏医药》
CAS
CSCD
1992年第5期240-243,共4页
Jiangsu Medical Journal
关键词
心肌缺血
再灌注
心律失常
Cardiac ischemia
Reperfusion
Triggered activity
Arrhythmias
