摘要
本文报道了在异搏定诱导的心衰犬中纳洛酮对血流动力学的影响。结果表明,纳洛酮能明显增加心衰犬的心排量(CO),心指数(CI),降低左室舒张末期压(LVEDP)及肺毛细楔嵌压(PWP)。提示纳洛硐能有效地改善心衰犬的心功能。
Effect of naloxone on hemodynamics was studied inverapamil-induced canineheart failure.Results showed that naloxone could markedly increase cardiac output(CO)and cardiac index(CI).And it could decrease left ventricular end-diastolic pressure(LVEDP)and pulmonary capillary wedge pressure(PWP)in canine heart failure.Theaction of Naloxone may be correlated with the antagonism of cardiac depression resultelfrom the direct inotropic action of endogenous opiate peptideg(EOP).
出处
《江苏医药》
CAS
CSCD
1992年第5期237-239,共3页
Jiangsu Medical Journal
关键词
纳洛酮
心力衰竭
血液动力学
Naloxone
Heart failure
Hemodynamics
Endogenous opiate peptides
