摘要
应用乙基亚硝胺(DEN)腹腔注射制造大鼠肝纤维化模型,分别选用国产RNA 和CoQ_(10)作治疗药物,另设正常对照和病理对照组。四组动物分三批于首次给药后第40、70、100天活杀。血清学检查显示RNA 治疗组血清谷丙转氨酶、单胺氧化酶(MAO)、N-乙酰-β-氨基葡萄糖苷酶(NAG)及血清五种意义较大氨基酸水平的升幅较小,与病理对照和CoQ_(10)治疗组相比有显著差异。光镜检查也显示RNA 治疗组肝细胞变性、坏死的程度以及胶原纤维定量代表的肝纤维化程度都比较轻,有显著意义。电镜检查从超微结构水平也证实了上述结果。
We used native RNA and CoQ_(10) seperately to treat rats hepatic fibrosis induced by intraperitoneal injection of Diethynitrosamine(DEN).On the 40th,70th,100th daysafter injection,rats were killed in four groups on three times.Serofogieal examinations sho-wed that the Glutamic pyruvic transaminase(GPT),Moaoamine oxidase(MAO),N-acetyl-β-glucosaminidase(NAG)and five kinds of important serum amino acid have slightly inc-reases in RNA treated group,The above investigation revealed evident sigaificance ascompared with the pathological control and the group treated by CoQ_(10) Under microscopic exa-mination,the degree of hepatocytic necrosis,degeneration and the quantity of collagenenesis.were rather mild.Such changes had also been proved at the ultrastructural level.
出处
《江苏医药》
CAS
CSCD
1992年第2期63-65,共3页
Jiangsu Medical Journal
关键词
RNA
肝纤维化
病理学
RNA
Diethylnitrosamine(DEN)
hepatic fibrosis
pathological examination
