摘要
4例短期CAPD(平均2.6月)者用高效液相色谱法测定血浆16种氨基酸及总必需氨基酸/总非必需氨基酸、酪氨酸/苯丙氨酸、丝氨酸/甘氨酸与缬氨酸/甘氨酸等四项比值,结果CAPD 组总必需氨基酸及缬氨酸、异亮氨酸、色氨酸较对照组明显降低,苯丙氨酸显著升高;总非必需氨基酸及天冬氨酸、谷氨酸、甘氨酸、丙氨酸明显升高,丝氨酸显著降低。表明短期CAPD 未能纠正尿毒症的血浆氨基酸谱异常,降低的四项比值亦无改善。
In four short-term CAPD patients(mean 2.6 months),we investigated the P'Splasma free concentrations of 16 kinds of amino acids by HPLC method and 4 it(?)ms of ra-tio were calculated,i.e.total essential amino acids/total non-essential amino acids,tyro-sine/phenylalanine,serine/glycine and valine/glycine.As compared with control group's,it was found that the CAPD group's concentrations of plasma total essential amino acidsand valine,isoleucine,tryptophan were decreased markedly but phenylalanine was increa-sed;while the levels of total non-essential amino acids and aspartic acid,glutamic acid,glycine,alanine were significantly higher and serine was lower than those of the controlgroup.We conclude that short-term CAPD does not correct the abnormal plasma aminoacid levels in uremic patients and it makes little improvement on the 4 ratios as mention-ed above.
出处
《江苏医药》
CAS
CSCD
1992年第1期11-13,共3页
Jiangsu Medical Journal
关键词
腹膜透析
氨基酸
血浆
尿毒症
Continuous ambulatory peritoneal dialysis(CAPD)
Amino acids Plasma Uremia High performance liquid chromatography(HPLC)
