摘要
成年雄性SD大鼠灌胃给昆明山海棠恨的乙醇提取物(简称ATH),每日0.3g/kg,6周后所有用药鼠均丧失生育力,检测其附睾尾精子活率及密度均明显低于对照。继续给维持量(0.2g/kg)ATH16周,停药5周后生育力及附睾精子完全恢复,所测的其它各项指标包括体重、附性腺重量、睾丸、附睾及主要脏器的组织学、血常规及淋巴细胞转化试验均与对照组无显著性差异。结果表明,在雄性SD 大鼠,低剂量的ATH 长期(22周)给药所致的不育是完全可逆的,且不遗留任何明显毒副作用。
An alcoholic extract of the root of Tripterygium hypoglaucum (ATH) wasgiven P.O.to adult male SD rats at the dose of 0.3g/kg/d.At the end of 6th week,alltreated rats became infertile.The motility and density of epididymal spermatozoa were si-gnificantly lower in the treated rats than in the control rats.ATH was given continuallyat the maintenance dose of 0.2g/kg/d for another 16 weeks.It was found that both the fert-ility and epididymal spermatozoa recovered completly 5 weeks after cessation of treatment.Other parameters including body weight,weights of accessory sex organs,histology oftestis,epididymis and important somatic organs,serum testosterone,blood routine andlymphocytes transformation assay were all examined,and there was no significant diffe-rence from those of controls.Results show that long-term(22 weeks)administration oflow dose of ATH is able to cause reversible infertility in male SD rats,and it does notremain any obvious side effect.
出处
《江苏医药》
CAS
CSCD
1992年第1期26-28,共3页
Jiangsu Medical Journal
关键词
昆明山海棠
雄性
抗生育
Tripterygium hypoglaucum
Male antifertility
Reversibility of fertility
