摘要
目的 探讨非特异性间质性肺炎的诱发因素、症状、体征、治疗及预后。方法 对 16例符合NSIP诊断病人的临床资料进行回顾性分析。结果 有吸烟、养宠物和基础疾病三因素之一NSIP者占患NSIP总人数 94 % ,无此三因素之一者占 6 %。用皮质激素组 (简称皮组 )治愈率 6 2 % (5例 ) ,非皮质激素组 (简称非皮组 )治愈率 37% (3例 ) ,P <0 .0 5有显著性差异 ;临床治愈 81%(13/16 ) ,皮组 87% (7/8例 ) ,非皮组 75 % (6 /8例 ) ,P >0 .0 5两组无显著性差异。Velcro罗音的消散 :皮组有效率 71% ;非皮组有效率 33% ,P <0 .0 1两组有显著性差异 ;HRCT磨玻璃样改变消退 :皮组有效率 87% (7/8) ;非皮组有效率 6 0 % (5 /8) ,P <0 .0 5有显著性差异 ;伴条索网格影消除率 ,皮组 75 % ;非皮组 0 ,P <0 .0 1有显著性差异 ;阻塞性通气障碍恢复正常率 :皮组 71% ;非皮组 10 %,P <0 .0 1有显著性差异。疗程 :激素组 ,平均治疗 (2 1± 9)d ,非激素组平均治疗 (38± 11)d。两组治疗时间t检验P <0 .0 1,显著性差异。结论 抽烟 ,养猫狗等宠物以及一些如陈旧性肺结核、慢性胃炎胃溃疡、肝囊肿等慢性基础疾病者是NSIP的易感诱发因素 。
Objective To explore the evoking factors, symptoms, physical signs, therapy, and prognosis of nonspecific interstitial pneumonia(NSIP).Methods 16 cases of NSIP were retrospectively analyzed.Results Ninety four percent of the patients had one of three risk factors , such as smoking, pets feeding and underlying disease. The remaining 6% patients had none of the three risk factors. The patients were nonselectively divided into two groups: respectively receiving therapy containing steroid (TCS) or nonsteroid(TCNS).The rates of curing were 62% and 37% respectively in TCS group and TCNS group, and the difference was significant( P <0.05).The rates of dissipation of Velcro noise in lung were respectively 71% in TCS group and 33% in TCNS group ,and the difference was significant( P <0.01).The rates of ground glass attenuation (GGA) melted in HRCT were respectively 87% in TCS group and 60% in TCNS group ,and the difference was significant( P <0.05).The rates which also had linear opacities ,vessels and reticulation in HRCT findings were respectively75% in TCS group and 0% in TCNS group ,and the difference was significant( P <0.01).The rates of obstructive ventilation obstacle in lung function resumed were respectively 71% in TCS group and 10% in TCNS group, and the difference was significant( P <0.01).The mean times of therapy duration were 21± 9 days in TCS group and 38±11 days in TCNS group, and the difference of the duration was significant( P <0.01). Conclusion The three risk factors of smoking,pet feeding and underlying disease,such as old tuberculosis ,gastritis or ulcer and hepatic cyst,contuibute to the evoking factors of NSIP.The steroid is a valid component in the therapy of NSIP.
出处
《重庆医学》
CAS
CSCD
2003年第7期827-829,共3页
Chongqing medicine
