摘要
目的 评价老年晚期非小细胞肺癌患者对联合化疗方案的疗效、毒副反应及其耐受性。方法 以健择联合顺铂、盖诺联合顺铂、紫杉醇联合顺铂三方案治疗老年晚期非小细胞肺癌 (NSCLC) 2 2例 ,观察其化疗效果和不良反应。结果 全组共完成86个周期 ,中位周期数 4。总有效率 4 5 .4 5 % ,中位生存期 14 .5个月 ,1年生存率 6 0 .4 %。最常见的毒副反应为骨髓抑制 ,发生率95 .4 7% ,其中Ⅰ度 2 2 .74 % ,Ⅱ度 4 5 .4 5 % ,Ⅲ度 2 2 .74 % ,Ⅳ度 4 .5 4 %。结论 老年非小细胞肺癌患者对于偏小剂量的联合化疗耐受良好 ,毒副反应较轻 。
Objective To estimate the efficacy, side effects and tolerance of combination chemical therapy in old patients with late non small cell lung cancer (NSCLC).Methods Twenty two patients were treated with gemcitabine + cisplatin, vinorelbine + cisplatin and paclitaxel + cisplatin respectively. The efficacy and side effects were observed after treatments.Results Eighty six cycles were completed totally and median was four. The total response rate was 45.45%, median survival time was 14.5 months, one year survival rate was 60.4%. Bone marrow inhibition was most common in all side effects. Its incidence rate was 95.47%, includingⅠdegree 22.74%, Ⅱ degree 45.45%, Ⅲ degree 22.74%, Ⅳ degree 4.54%.Conclusion Old patients with late non small cell lung cancer have good tolerance, light side effects and satisfied preliminary efficacy to combination chemical therapy.
出处
《重庆医学》
CAS
CSCD
2003年第7期832-833,共2页
Chongqing medicine
