摘要
目的 :研究MM患者与正常人骨髓基因的差异表达。方法 :应用cDNA芯片技术对 1 0例初诊多发性骨髓 (MM)患者和 1 0名正常骨髓的单个核细胞的mRNA进行检测。结果 :在 2 0 4 8条基因中共发现差异表达基因5 6 6条。在MM中 2 37条表达增加 ,32 9条表达降低。结论 :MM的发生发展涉及多基因的改变 。
Objective To determine the difference in gene expression between human multiple myeloma (MM) and normal bone marrow. Methods cDNA chip was used to detect the mRNA of mononuclear cell from 10 untreated MM patients and 10 cases of normal bone marrow. Results Of the 2 048 genes, we found 566 different expression genes, of which the expression of 237 genes was higher and 329 lower in MM than in the normal bone marrow. Conclusion Many genes may be involved in the pathogenesis of MM.cDNA chip technology is an effective tool in the study of tumor related genes.
出处
《湖南医科大学学报》
CSCD
北大核心
2003年第3期201-205,共5页
Bulletin of Hunan Medical University
基金
国家自然科学基金资助项目 (No .3 9880 0 2 1)
国家教育部<2 1世纪教育振兴行动计划>重点实验室访问学者基金资助项目
