摘要
高效液相色谱内标法定量分析血浆中盐酸头抱他美酯活性代谢产物头孢他美酸的含量,并将20名健康男性受试者分两组同时进行单剂量二交叉试验,单剂量口服盐酸头孢他美酯试验片,用上述方法测头抱他美酯的血药浓度经时过程,并计算两者的主要药代动力学参数。经方差分析,均表明无显著性差异。由两种制剂的 AUC_(0—12)计算,试验片的相对生物利用度为98.5±6.2%。AUC、Cmax 对数转换后经单双侧 t 检验表明,试验片和参比片生物等效。
Pharmacokinetics and relative bioavailability of cefetamet pivoril in healthy volun- teers were studied by cross-over experiments.20 healthy male examiners were separated into two groups,hydrochloric acid cefetamet pivoril tablets,were taken by the two groups respectively in OP dosages.Internal probe of HPLC was used to quantitively calculate the content changing of cefetamet pivoril acid,the metabolic product of cefetamet pivoril,in examiners'blood.The major parameters on medicine metabolic kinetics of the two groups were.respectively.Variance tests did not show significant difference between the two groups.AUC_(0-12)values indicated that the relative bioavailability of the testing tablets was 98.5±6.2%.Single-and double-sides t-test of lnAUC and lnC_(max)showed that the testing tablet had the comparable effect with the standards.
出处
《黑龙江医药》
CAS
2003年第4期261-262,共2页
Heilongjiang Medicine journal
