摘要
目的 了解狼疮肾炎终末期肾功能衰竭患者肾外狼疮活动情况。方法 对 1 990年至 1 998年间住院并定期进行持续不卧床腹膜透析或血液透析的狼疮肾炎终末期肾功能衰竭患者 6 9例透析前后肾外狼疮活动情况进行回顾性总结。结果 透析前 1个月至 3月 3 5 %(2 4 /6 9)的狼疮肾炎终末期肾衰患者具有肾外狼疮活动表现 ,透析第 1年中狼疮活动病例较透析前增加 5 7%(3 9/6 9) (P <0 .0 5 )。以后 ,随透析时间延长狼疮活动逐渐减少 (P <0 .0 5 )。抗核抗体 ,抗双链DNA抗体 ,低C3血症阳性率也随时间延长降低 (P <0 .0 5 )。结论 狼疮肾炎终末期肾功能衰竭患者开始透析第 1年狼疮活动增加 ,短期激素治疗缓解肾外狼疮活动症状。
Objective To investigate the evaluation of extrarenal activity in lupus nephritis patients with end stage renal disease (ESRD).Methods 69 patients who received maintenance dialysis at the Second Affiliated Hospital of Lanzhou Medical College from 1990～1998 were studied retrospectively. Results 24 patients (35%) had clinical lupus activity before dialysis. But during the first year of dialysis, 39 patients (57%) experienced lupus activity, and decreased for years thereafter (P<0.05).serologic abnormalities improved gradually over time (P<0.05). Conclusions Extrarenal lupus activity in lupus nephritis after ESRD is not common, especially during the first year of dialysis,which can be relieved by using of short -term coticoid.
出处
《兰州医学院学报》
2003年第2期31-33,共3页
Journal of Lanzhou Medical College
关键词
狼疮性肾炎
肾外狼疮活动
透析治疗
免疫学
激素治疗
Lupus nephritis End-stage renal disease Peritoneal dialysis Hemodialysis Lupus activity
