摘要
目的 评价倍他乐克片和卡维地洛片治疗高血压并发无症状性心肌缺血患者的降压、减少心肌缺血的效果。方法 6 5例患者被随机分成 2组 ,分别服用倍他乐克片 (倍他乐克组 )和卡维地洛片 (卡维地洛组 ) ,比较治疗前及治疗 8周后对心率、坐位血压、4 8h动态心电图中心肌缺血的影响。结果 两组心率、坐位血压、缺血次数及缺血时间均明显下降 (P <0 .0 5 )。血压下降两组间比较卡维地洛组优于倍他乐克组 (P <0 .0 5 ) ,心率、缺血次数和缺血时间两组比较无统计学意义。两组不良反应发生率无明显差异 (P >0 .0 5 )。结论 倍他乐克和卡维地洛均有较好的降压作用 。
Objective It is to evaluate the antihypertensive and relieving myocardial ischemia effects of betaloc and carvedilol on hypertension with silent myocardial ischemia (SMI). Methods 65 patients were divided into two groups at random. Betaloc group were treated with betaloc while carvedilol group were treated with carvedilol. After eight weeks of treatment, heart rate, office blood pressure and SMI during 48-hour ambulatory electrocardiography were compared with those before treatment. Results Heart rate, office blood pressure, frequency of ischemia episodes and total ischemia duration of two groups were significantly decreased ( P <0.05). Decreasing of office blood pressure in carvedilol group was prior to that of betaloc group, there was significant difference ( P <0.05). The changes of heart rate, frequency of ischemia episodes and total ischemia duration in two groups was indistinctive ( P >0.05). There was no obvious difference between the side effects of two groups ( P >0.05). Conclusion Both betaloc and carvedilol have better antihypertensive effect and carvedilol is more effective than betaloc.
出处
《现代中西医结合杂志》
CAS
2003年第15期1579-1581,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
