摘要
目的 观察拟血管性痴呆小鼠大脑皮层组织一氧化氮 (NO)的变化及电针的影响 ,探讨血管性痴呆的发病机理及电针的作用机制。方法 复制脑缺血再灌注拟血管性痴呆小鼠模型 ,电针肾俞、膈俞、百会穴 ,并与喜德镇对照 ,分别于术后 7天、15天、3 0天 ,测定各组小鼠大脑皮层组织NO含量。结果 模型动物的NO含量在 15天有一高峰。电针和喜德镇对模型NO含量在 7～ 3 0天观察期内未见明显影响。结论 模型动物的NO含量在 15天有一高峰。在 7～ 3 0天期间 ,电针对该模型的治疗作用可能非NO途径 ,针刺即时至 7天内对NO的影响 ,有待进一步观察。
Objective To observe the Change on nitric oxide NO content in synthetic vascular dementia mouse’s cerebral cortex tissue and the effect of electrical acupuncture, and to study the mechanism of the disease of the vascular dementia and treating vascular dementia with electrical acupuncture.Method To duplicate ischemia reperfusion synthetic vascular dementia model mouse,make electrical acupuncture on acupoints including Shenshu,Geshu and Baihui,compare with Hydergine and determine the NO content of mice's cerebral cortex tissue in each group after seven days,fifteen days and thirty days of operation respectively.Result The NO content of model animal reached the peak point at the fifteenth day.Electrical acupuncture and Hydergine had obvious effect on NO content during the period of seven thirty days.Conclusion The NO content of model animal reached the peak point at the fifteenth day,the treating function of electrical acupuncture was not obtained NO means probably and it needs further observation about the effect of electrical acupuncture on NO within seven days.
出处
《中国行为医学科学》
CSCD
2003年第3期249-250,共2页
Chinese Journal of Behavioral Medical Science
基金
河北省科技攻关计划项目 (No .0 0 2 762 0 2D)
关键词
拟血管性痴呆
小鼠
大脑皮层
一氧化氮
电针
Synthetic vascular dementia
Mouse
Cerebral cortex tissue
NO
Electrical acupuncture
