摘要
目的 :研究瘦素 (leptin)与原发性高血压 (EH)左室肥厚 (LVH)的相关性 ,从而进一步探讨LVH的发病机制。方法 :随机选择确诊EH男性患者 4 1例 ,选正常健康男性 2 3例作为对照。晨空腹测定血清leptin水平、血清胰岛素和血糖水平 ,胰岛素与血糖乘积的倒数即胰岛素敏感性指数 (ISI)作为评价胰岛素抵抗 (IR)的指标。心脏彩超测定室间隔厚度 (IVST)、左室后壁厚度 (PWT) ,IVST与PWT之和即左室壁厚度和 (SWT)作为评价LVH的指标。采用相关分析、多元逐步回归等统计方法进行评价。结果 :EH组与对照组具有可比性 ,两者之间leptin水平有统计学意义 (P <0 .0 1)。在EH组 ,leptin水平与SWT显著相关 (r =0 .5 1,P <0 .0 1)。多元逐步回归分析显示 ,血清leptin水平和ISI与SWT相关性好。 结论 :男性血清leptin水平与EHLVH具有良好的相关性。
Objective:To investigate the relationship between leptin and left ventricular hypertrophy (LVH) in patients with essential hypertension .Methods:Forty one male patients with primary hypertension were randomly selected as the hypertensive group. They had not taken any drug which might affect blood pressure for at least 2 weeks. Twenty three healthy male were as the control group. Blood samples were obtained in the early morning before any food was taken. The fasting leptin, insulin and glucose levels and the insulin sensitive index (ISI, calculated by log of insulin×glucose) were tested as the evaluation of insulin resistance (IR). The interventricular septum thickness, left posterior wall thickness and the sum of wall thickness (SWT ie, septal + posterior wall thickness) were assessed by Doppler echocardiography. The associated analysis and a multiple linear regression analysis were used for statistical analysis.Results:There was a significant difference in the serum leptin levels between the hypertensive group and the control group (P< 0.01 ). In the hypertensive group, the serum leptin levels was significantly related with SWT (r= 0.51 ,P< 0.01 ). A multiple linear regression analysis indicated that there was good correlation between the serum leptin levels and ISI and SWT.Conclusion:Our study suggested that male fasting leptin levels was related with left ventricular hypertrophy in essential hypertension.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2003年第7期392-395,共4页
Journal of Clinical Cardiology
关键词
瘦素
左室肥厚
高血压
胰岛素抵抗
Leptin
Left ventricular hypertrophy
Hypertension
Isulin resistance
