摘要
目的 :探讨抗癫类药物血药浓度监测结果对临床个体化给药的指导意义。方法 :运用荧光偏振免疫法测定血药浓度 ,对我院 1999年～ 2 0 0 2年 6月主要抗癫药丙戊酸钠、卡马西平血药浓度监测结果进行分析、评价。 结果 :抗癫类药物有效剂量个体差异大 ,联合用药时抗癫类药物体内的相互作用复杂 ,血药浓度监测对临床调整用药剂量有指导意义。结论
Objective: To investigate the directive significance of monitoring serum concentrations of sodium valproate and carbamazepine for the clinical individual medication. Methods: Fluorescence polarization immune analysis was applied to measure and evaluate the serum concentrations of major antiepileptics used in our hospital during 1999 June 2002, such as carbamazepine and sodium valproate. Results: There was visible individual difference in the effective dose of antiepileptics. Concomitant use of antiepileptics had complicated in vivo interactions. Monitoring the serum concentrations had directive significance for adjusting the dosage used. Conclusion: The monitoring of serum concentration is one of the important measures to ensure the clinical therapeutic effectiveness and safety. [
出处
《药学服务与研究》
CAS
CSCD
2003年第2期105-107,共3页
Pharmaceutical Care and Research
关键词
血药浓度监测
丙戊酸
卡马西平
plasma concentration, monitoring
valproic acid
carbamazepine
