摘要
通过异丙肾上腺素及垂体后叶素诱发急性心肌缺血模型 ,观察人参果皂苷 (GFS)对实验性心肌缺血的保护作用。结果表明 ,GFS 30、60mg/kg对皮下注射异丙肾上腺素缩短小鼠的常压缺氧状态下的存活时间均具有明显对抗作用 ,2 0、40mg/kg均可明显减轻静脉注射垂体后叶素诱发的大鼠急性心肌缺血心电图 (ST段抬高及T波高耸 )变化程序 。
Protective effect of Ginseng fruin saponins(GFS)on experimental myocardial ischemia was observed with acute myocardial ischemia model induced by isoprenaline (Isop.)in mice and posterior-pituitary (Pit)in rats.The results showed that GSF(30.60mg/kg,ip)could prolong significantly survival time in normal pressure anoxia induced by Isop. and GSF(20,40mg/kg,ip)could decrease degrees of myocardial ischemia ECG induced by Pit.it is indicated that GSF has the significant protective effect on myocardial ischemia.
出处
《人参研究》
2003年第2期2-4,共3页
Ginseng Research
基金
国家重点科技攻关项目 ( 96- 90 1 - 0 5 - 1 5 5 )
