摘要
目的 :了解肺癌患者呼吸道感染的病原菌及其耐药特点。方法 :对我院 2 0 0 0年 1月～ 2 0 0 2年 1月肺癌患者痰标本所分离细菌进行回顾性分析。结果 :肺癌病人呼吸道感染以G-菌为主占 5 4 5 % ,其次是真菌 2 1 9%及G+ 菌 14 1%。G-菌中以沙雷菌属 (32 2 % )、大肠埃希菌和铜绿假单胞菌 (9 7% )为主 ,在大肠埃希菌中 ,产超广谱 β 内酰胺酶株 (ESBLS)占 4 0 6 % ;真菌以白色假丝酵母菌 (87 8% )为主 ;G+ 球菌中以凝固酶阴性葡萄球菌为主 (76 9% ) ,耐苯唑西林凝固酶阴性葡萄球菌 (MRSCN)占 6 3 6 %。所分离细菌除对舒普生、特治星、亚胺培南及万古霉素耐药率较低外 ,常用抗生素显示较高的耐药率。结论 :肺癌患者呼吸道感染的病原菌以G 菌为主 ,而真菌和G+ 菌亦不容忽视 ,且大多数病原菌耐药率较高 ,临床合理、规范使用抗生素是当务之急。
Objective:To know for the bacteria of infection in respiratorytract(IRT)of patients with lung cancer and the drug resistance.Method:The bacteria were isolated from sputum of patients with lung cancer and their drug resistance were analysed during Jan.2000-Jan.2002.Result:The most prevailing isolates of pathogens in IRT of patients of lung cancer were G -(54.5%),then fungi (21.9%) and G + (14.1%).Serratia in G - bacteria(32.2%) then Escherichia coli(14.5%)and Pseudomonas aeruginosa(9.7%),40.6% Extenden-spectrum β-lactamase(ESBLS) were inspected in Escherichia;Candida albicans(87.8%) was main type of fungi and staphylococcus of coagulase negative(76.9%) was main germs in G +. Among staphylococcus of coagulase negative MRSCN were 63.6%.All the isolated pathogens had high drug-resistence rate for common antibitics except for sulbactam cefoperazona?piperacillin/tozobactam?emipenem and rancomycin. Conclusion:The main pathogens in IRT of patients with lung cancer was G - bacteria,but fungi and G + bacteria were also important.The most isolated pathogens were multidrug-resistence,it was urgent for clinical doctors to use antibiontics rationally and rightly.
出处
《中国微生态学杂志》
CAS
CSCD
2003年第3期162-162,共1页
Chinese Journal of Microecology
