摘要
目的 检测C erbB 2癌基因在煤工尘肺并发肺癌患者的表达与单纯肺癌患者的差异及与临床病理的关系。方法 采用免疫组织化学方法分别检测 32例煤工尘肺并发肺癌者及 30例单纯肺癌者的C erbB 2表达。结果 煤工尘肺肺癌组患者C erbB 2阳性表达率为 5 3.13% ,单纯肺癌组患者C erbB 2阳性表达率为 2 6 .6 7% ,差异有显著性 (P <0 .0 5 ) ;两组中有淋巴结转移者C erbB 2阳性表达率 (尘肺组 70 .5 9%、单纯肺癌组 5 0 .0 0 % )与无淋巴结转移者 (尘肺组 33.33%、单纯肺癌组 11.11% )的差异有显著性 (P <0 .0 5 ) ;C erbB 2阳性表达者预后差 ,与病理组织学类型无关。结论 C erbB 2是煤工尘肺并发肺癌的重要的调控基因之一 ,可作为判断有无淋巴结转移及预后的参考指标。
Objective To study the difference in the expressions of C-erbB-2 gene between the coal miners with pneumoconiosis complicated by pulmonary cancer and the controls with single pulmonary cancer,and its relation to clinical pathology. Method Measuring the expressions of C-erbB-2 in 32 cases of pneumoconiosis complicated by pulmonary cancer and those in 30 cases of pulmonary cancer by means of immunohistochemistry. Results The positive expression rate in 32 cases of pneumoconiosis complicated by pulmonary cancer was 53.13% whereas that in 30 cases of single pulmonary cancer was 26.67%( P <0.05);the positive expressions of C-erbB-2 in patients with lymph node metastasis(70.59% in pneumoconiosis group,50.00% in controls) were significantly different from those without lymph node metastasis(33.33% in pneumoconiosis group,11.11% in controls)( P < 0.05) .The prognosis on patients with positive expressions of C-erbB-2 was poor,and was not related to pathologic category. Conclusion C-erbB-2 gene may be an important regulating gene in the coal miners with pneumoconiosis complicated by pulmonary cancer,and as a reference index to determine lymph node metastasis and prognosis.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2003年第3期169-171,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
