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Ⅰ型超敏反应的迟发相 被引量：3

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摘要 Ⅰ型超敏反应的迟发相反应发生于速发相之后的 8～ 2 4h ,其特征是以嗜酸粒细胞为主的炎细胞浸润。肥大细胞是迟发相反应的主要启动细胞。Th2淋巴细胞起调控作用。嗜酸粒细胞趋化因子吸引嗜酸粒细胞至炎症区 ,并释放大量炎症因子及多种酶类 ,发生持续性炎症反应 ,导致组织损伤。此外 ,中性粒细胞、单核 /巨噬细胞也通过分泌生物活性物质及酶类而参与迟发相反应。
作者 沈柱 刘玉峰
机构地区 第四军医大学西京医院皮肤科
出处 《国外医学（皮肤性病学分册）》 2003年第4期238-240,共3页 Foreign Medical Sciences(Section of Dermatology and Venereology)
关键词 Ⅰ型超敏反应 迟发相 嗜酸粒细胞 淋巴细胞
分类号 R392 [医药卫生—免疫学]
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参考文献17

  • 1Nagai H, Sakurai T, Inagaki N, et al. An immunopharmacological study of the biphasic allergic skin reaction in mice. Biol Pharm Bull,1995, 18(2) :239 -245.
  • 2Nagai H, Abe T, Yamaguchi I, et al. Role of mast cells in the onset of IgE-mediated late-phase cutaneous response in mice. J Allergy Clin Immunol, 2000, 106(1 Pt 2) :S91 -98.
  • 3Sengoku T, Sato S, Sakuma S,et al. Characterization of Ascaris-induced biphasic skin allergic reaction model in mice: possible roles of mast cells in early-phase and CD4 - positive T cells in late-phase reactions. Pharmacology, 2001,63(2) :82 - 89.
  • 4Kimata M, Abe T, Yamaguchi I,et al. Prednisolone inhibits an IgE-mediated late-phase allergic cutaneous reactionby interfering with the activation of mast cells in mice. Pharmacology, 2001, 62(1) : 17 -22.
  • 5Zweiman B, Moskovitz AR, von Allmen C. Comparison of inflammatory events in skin sites with and without cutaneous late-phase reactions after prominent immediate IgE-mediated responses. J Allergy Clin Immunol, 1998, 101(1 Pt 1) : 110 - 115.
  • 6Pawankar R, Yamagishi S, Yagi T. Revisiting the roles of mast cells in allergic rhinitis and its relation to local IgE synthesis. Am J Rhinol,2000, 14(5) :309 -317.
  • 7Schmidt J, Fleissner S, Heimann-Weitschat I, et al. Histamine increases anti-CD3 induced IL - 5 production of TH2 - type T cells via histamine H2 - receptors. Agents Actions, 1994, 42(3 - 4) : 81 -85.
  • 8Togawa M, Kiniwa M, Nagai H. The roles of IL -4, IL -5 and mast cells in the accumulation of eosinophils during allergic cutaneous late phase reaction in mice. Life Sci, 2001, 69(6) :699 -705.
  • 9Barata LT, Ying S, Meng Q, et al. IL-4 - and IL-5 -positive T lymphocytes, eosinophils, and mast cells in allergen-induced late-phase cutaneous reactions in atopic subjects. J Allergy Clin Immunol,1998, 101(2 Pt 1) :222 -230.
  • 10Malaviya R, Uckun FM. Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells. J Immunol,2002, 168(1):421 -426.

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国外医学（皮肤性病学分册）
2003年 第4期

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