摘要
为探讨 β -绒毛膜促性腺激素 (β -HCG)、一氧化氮 (NO)和内皮素 - 1(ET - 1)在妊高征发病中的作用 ,用放射免疫分析法或Cortas法分别对 5 8例妊高征患者 (妊高征组 )、2 7名正常晚期妊娠妇女 (正常妊娠组 )以及2 0名未妊娠妇女 (正常对照组 )血中 β -HCG、NO和ET - 1水平进行了检测。结果是 :妊高征患者血中 β -HCG和ET - 1水平高于正常妊娠妇女 ,β -HCG和ET - 1水平越高 ,妊高征病情越严重 ;中、重度妊高征患者血清NO水平低于正常妊娠妇女 ;中、重度妊高征患者血中 β -HCG与ET - 1呈明显正相关 ,而NO与ET - 1呈明显负相关。结论是 :妊高征血管内皮细胞损伤与胎盘滋养细胞功能失调有关。
To study the role of serum β-human chorionic gonadotropin (β-HCG),nitric oxide(NO)and plasma endothelin-1(ET-1) levels in patients with pregnancy induced hypertension (PIH),serum β-HCG and ET-1 were determined by radioimmunoassay,and plasma NO was determined with Cortas′ method in 58 patients with PIH,27 normal pregnant women and 20 normal non-pregnant women.Results:the levels of β-HCG and ET-1 in patients with PIH were significantly higher than those in healthy pregnancies ( P < 0.01). There was a positive correlation between the β-HCG and ET-1 levels;the higher the β-HCG and ET-1 levels, the more severe of the PIH.The levels of serum NO in patients with moderate and severe PIH decreased significantly than those in healthy pregnancies( P <0.01).There was a positive correlation between the β-HCG and ET-1 levels( r =+0.577, P <0.01).There was a negative correlation between the NO and ET-1 ( r =-0.608, P <0.01).The results suggest that the dysfunction of the placental cells may be associated with the endothelial cell damage in PIH patients.
出处
《标记免疫分析与临床》
CAS
2003年第2期92-95,共4页
Labeled Immunoassays and Clinical Medicine
