摘要
目的 评价肌肉注射小剂量咪唑安定及肠道解痉剂在结肠镜检查中的作用。方法 选择2001年12月至2002年5月在北京协和医院门诊行结肠镜检查的120例患者,并在患者知情同意后,按就诊顺序均分为4组:Ⅰ组(咪唑安定)、Ⅱ组(咪唑安定+匹维溴胺)、Ⅲ组(咪唑安定+奥替溴胺)、对照组,观察止痛、镇静、抗焦虑、记忆情况及对血压、心率的影响。结果 Ⅰ组、Ⅱ组和Ⅲ组均较对照组检查中疼痛明显减轻。与前次检查比较,Ⅰ组与Ⅲ组疼痛有显著下降。用肠道解痉剂者检查前肠道准备中腹痛显著轻于不用者。用咪唑安定各组镇静状态好于对照组。各组在检查后的焦虑视觉类比均有明显改善,记忆试验以及检查前、中、后的血压、心率差异均无显著性意义。结论 肌肉注射小剂量咪唑安定在结肠镜检查中有很好的止痛、镇静作用,同时口服匹维溴胺或奥替溴胺可减轻检查前肠道准备中的疼痛,小剂量咪唑安定肌肉注射对心率及血压无影响。
Objective To evaluate the effect of Midazolam and Midazolam with Pinaverium Br (Dicetel) or Otilonium Br ( Spasmomen) on colonoscopy. Methods One hundred and twenty outpatients undergone colonoscopy between 2001. 12 -2002. 5 in PUMC hospital were enrolled in their consent. The patients were divided into four groups in a longitudinal sequence; Control group, Group Ⅰ (Midazolam 3 mg i. m. 30 min before colonoscopy) , Group Ⅱ (Midazolam , Dicetel 100 mg t. i. d. x 3d before examination) and Group Ⅲ ( Midazolam, Spasmomen 40 mg×2) . Results (1) During colonoscopy the pain scales in groups Ⅰ , ⅡI and M were significantly lower than in control group. (2) In patients with repeated colonoscopy, the pain scales in this examination were remarkably lower than those in the previous examination of groups Ⅰ andⅡ , no significant corresponding changes in control and II groups. (3 ) The pain scales of colonoscopy during preparation in groups Ⅱ andⅢ were lower than those in the other groups. (4) The sedation status was better in group Ⅰ, Ⅱ and Ⅲ than that in control group. (5 ) The anxiety visual analog test (AVAT) and status of anxiety inventory (SAI) 30 min after colonoscopy all were decreased in four groups and there was no significant difference in each group. (6 ) There was no significant difference in memory test of each group. ( 7 ) The patients' HR and BP during or before and after colonoscopy all were no significant changes in each group. Conclusion The good effects of Midazolam for colonoscopy were observed including analgesic and sedation, but no effect on HR, BP and memory. Dicetel and spasmomen can relieve pain during colonoscopy preparation.
出处
《中华消化内镜杂志》
2003年第3期175-178,共4页
Chinese Journal of Digestive Endoscopy
