摘要
目的 探讨磷霉素钠治疗下呼吸道感染的临床疗效和安全性。方法 将 118例患者随机均分为磷霉素钠组和头孢曲松钠组 ,分别给予磷霉素钠每天 8g和头孢曲松钠每天 4g分两次静滴 7～ 14d;观察临床症状、体征、血常规、X线胸片、痰细菌培养、治疗前后肝肾功能变化、细菌清除率及不良反应等。结果 磷霉素钠组和头孢曲松钠组临床治疗有效率分别为 83.1%、76 .3%,P>0 .0 5 ,无统计学差异 ;对革兰氏阳性球菌清除率分别为 94.7%、76 .5 %,P<0 .0 5 ,有差异 ,对革兰氏阴性杆菌清除率分别为 75 %、82 .4%及细菌总清除率分别为 83.3%、80 %,P>0 .0 5 ,无差异 ;两组均无明显不良反应。结论 磷霉素钠治疗下呼吸道感染疗效确切 ,细菌清除率高 ,尤其对革兰氏阳性球菌有良好作用 ,使用安全 ,价格低廉 ,值得临床推广使用。
Objective To investigate the clinical efficacy and safety of sodium fosfomycin on the lower respiratory tract infection. Methods One hundred and eighteen cases were randomly divided into two groups, namely the sodium fosfomycin group and the sodium ceftriaxone group. The two group cases were treated with sodium fosfomycin 8g per day and sodium ceftriaxone 4g per day, bid iv gtt. The course of treatment was seven days to fourteen days; The clinical symptom, sign, blood routine, chest X-ray, the phlegm bactria education, function variety of pre-treatment and post-treatment, bactria cluture rate and adverse effects ect were obser-ved. Results The effective rate of clinical treatment of the sodium fosfomycin and the sodium ceftriaxone were 83.1% and 76.3% respectively (P>0.05). There was no statistical difference; The bactria clearance rates of Gram-positive coccis were 94.7% and 76.5% respectively (P<0.05). There was significant difference. The bacterial clearance rates of Gram-negative bacteria were 75% and 82.4% respectively, and total bactria clearance rates were 83.3% and 80% respectively (P>0.05). There was no difference. There weren′t obvious adverse effects in these two groups. Conclusion The effect of sodium fosfomycin on the lower respiratory tract infection was reliable, the bactrial clearance rate was high, particularly to Gram-positive coccus.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2003年第6期361-363,共3页
Chinese Journal of Antibiotics
关键词
磷霉素
头孢曲松
下呼吸道感染
Fosfomycin
Ceftriaxone
Lower respiratory tract infection
