摘要
介绍了 7 氨基去乙酰氧基头孢烷酸化学法合成工艺 ,综述了酶法和发酵法合成7 ADCA的研究现状。生物法合成经济且环境友好 ,是工业中合成 7
amino desacetoxycephalosporanic acid(7 ADCA) is a key intermediate for the preparation of synthetic commercial cephalosporins. up to date, the methods favored in industry to prepare 7 ADCA involved complex chemical steps. These complex chemical processes are both expensive and noxious to the environment. With the increasing knowledge of strain improvement techniques, the production level of antibiotics increased dramatically in the past years. As a result, a lot of inventions related to the bioprocess of preparing 7 ADCA were reported. In this paper, several methods were reviewed, the entire synthsis of which, accordingly, was carried out using bioprocesses, and it is efficient and economical.
出处
《精细化工中间体》
CAS
2003年第3期1-3,共3页
Fine Chemical Intermediates
