摘要
越来越多的微生物基因组序列数据为系统地研究基因的调节和功能创造了有利条件 .由于蛋白质是具有生物功能的分子 ,蛋白质组学在微生物基因组的功能研究中异军突起、蓬勃发展 .微生物蛋白质组学的基本原则是 ,用比较研究来阐明和理解不同微生物之间或不同生长条件下基因的表达水平 .显而易见 ,定量分析技术是比较蛋白质组学中急需发展的核心技术 .
The rapidly accumulating data of sequenced microbial genomes allows to conduct systematic studies on microbial gene regulation as well as function. As proteins are often the functional molecules, proteomics is particularly booming in the functional studied of microbial genomics. Using comparative studies as the powerful tools, a fundamental principle in microbial proteomics is to elucidate and to understand the gene expression levels in different microorganisms or under different growth conditions. It is very obvious that the quantitative analytical techniques are highly required for comparative proteomics. The current status of the approaches applied to quantitative analysis of microbial proteomics were reviewed.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2003年第3期344-349,共6页
Progress In Biochemistry and Biophysics
