摘要
目的 观察慢性肾功能衰竭 (CRF)血液透析患者血清脂蛋白 (a) [Lp(a) ]水平的变化及其临床意义。方法 对 60例慢性肾功能不全患者的临床及实验室资料作回顾总结 ,分析血清脂蛋白 (a)的水平与心血管事件的关系。结果 CRF患者无论透析与否 ,其血Lp(a)水平均较对照组显著性升高(P <0 .0 5 )。血液透析 (HD)组Lp(a)水平升高及HDL C水平下降更明显 (P <0 .0 5 ) ,而血透组与非透析组血总胆固醇 (CHOL)、低密度脂蛋白 (LDL C)浓度差异无显著性。Lp(a)水平与心电图异常、超声心动图异常及心血管事件的发生呈正相关。结论 CRF患者存在严重的脂代谢紊乱 ,Lp(a)
Objective To observe the change and significance of lipoprotein (a) in patients with chronic renal failure (CRF) treated by hemodialysis (HD).Methods The clinical and laboratory data of 60 patients with CRF were collected and analyzed.The correlation between Lp(a) and cardiovascular events was investigated. Results The average level of serum Lp(a) in CRF patients was significantly higher than that in control group (P<0.05).The average level of serum HDL C in HD group was significantly lower than that in control group (P< 0.05). No difference was found in serum TG,LDL C,CHOL between HD group and non HD group.The serum Lp(a) level was positively correlated with clinical manifestations such as abnormal echocardiography,ECG and cardiac events.Conclusion The complicated changes of lipid metabolism are associated with hemodialysis.The increase of serum Lp(a) and the decrease of serum HDL C may be a risk factor for cardiovascular events in HD patients.
出处
《河北医药》
CAS
2003年第6期408-409,共2页
Hebei Medical Journal
