摘要
利用原子吸收分光光度法和组织切片形态学方法,测定了沙土鼠脑缺血30min 和60min 大脑皮层Na^+、K^+、Ca^(2+)和Mg^(2+)的变化,观察了缺血脑组织的形态学病理改变,进一步探讨缺血性脑水肿的病理机制。结果表明脑缺血30min 和60min 大脑皮层内Na^+、K^+和Ca^(2+)含量均明显增加,Mg^(2+)含量显著降低。缺血组皮层含水量增加,细胞和血管周围间质呈网化状态,细胞界线不清。提示缺血性皮层水肿和组织内Na^+、K^+潴留有关,Ca^(2+)、Mg^(2+)在脑缺血的病理生理过程中发挥重要作用,Ca^(2+)的损伤作用和Mg^(2+)保护作用的减弱可能是缺血神经元损伤的原因之一。
The purpose of this study was to measure the changes of Sodium(Na^+),potassium(K^+),Calcium(Ca^(2+))and Magnesium(Mg^(2+))in cerebral cortexby Atomic Absorption Spectrophotometry(AAS),and to observe the pathologicalchanges of the cortex bY general pathologicoanatomic method followiing acutecerebral ischemia.Th(?)results indica(?)ee that the content of Na^+,K^+ and Ca^(2+) incortex increasee and that of Mg^(2+) decreased sig(?)ificautly in cerebral ischemic 30min.and 60 min.groups.The water content of the cortex in ischemic groups wasobviously heightened compared with that of normal controlgroup.The spaces betweennervous cells and blood capillaries showed distinct network state.The demarcationsof the nervous cells were not clear.Our data sugest that the ischemic corticaloedema is related to retentioa of Na^+ and H_2O(warer)in nervous tissue.AndCa^(2+) and Mg^(2+) might play an importartt role in the pathophysiological processesof cerebral ischemia,where Ca^(2+) might damage and Mg^(2+) might protect thenervous tissue.
出处
《济宁医学院学报》
1992年第2期5-9,共5页
Journal of Jining Medical University
关键词
脑缺血
钠
钾
钙
镁
大脑皮层
Sodium
potassium
Calcium
Magnesium
Brain edema
Cerebral ischemia
Atomic Absorption Spectrphotometry
