摘要
目的 :研究颞下颌关节在不同强度持续性高正加速度 (+Gz)作用下的反应情况。方法 :雄性Wistar大鼠 6 0只随机分成 5组 ,A组为空白对照 ;B组地面固定 5min ;C组固定于离心机转臂上 ,俯卧位 ,头向轴心 ,+1Gz离心 5min ;D组体位同C组 ,+10Gz离心 30s,G增长率 0 5G/s,间隔时 +1Gz离心 6 0s ,连续每天 3次 ,每周 3d ,共 3周 ;E组 +Gz加载条件每天 5次 ,每周 4d ,其余参数同D组。各组动物分别取颞下颌关节作光镜观察和扫描电镜观察。结果 :A组、B组和C组未见异常 ,D组髁状突和关节盘胶原纤维排列紊乱 ,偶见胶原原纤维破坏 ,凝胶状物质菲薄但基本完整。E组髁状突和关节盘胶原纤维排列紊乱、断裂。凝胶状物质不完整 ,胶原纤维暴露断裂伴成纤维细胞脱落。结论
Objective:To analysis the Changes of Temporom a ndibular Joint(TMJ) Under +Gz Condition. Methods: 60 male Wistar rats were randomly divided into 5 groups( n =12). Group A was normally fed. G roup B was only fixed with rat kept devices for 5 minutes Group C was borne + 1Gz for 5 minutes. Group D was repeatedly exposed +10Gz (each for 30s, onset rat e about 0 5G/s, 3 times/d with +1Gz 1 minute intervals, 3d/wk, 3 weeks in total ) In group E 5 times/d and 4d/wk, other variables is the same as group D Tem poromandibular Joints and masticatory muscles from each group were respectively taken out and observed under microscope and SEM. Results: No abn ormal changes were observed in group A B and C But in Group D and E pathol ogic injuries were seen in TMJ and masticatory muscles in different degrees In group D, it can be seen that the arrangernent disorder disruption of collagen f ibers The gel like substances become very thin but roughly integrated In gr oup E, because most gel like substances disappeared, the dispose and breakdown of collagen fibers of condyle of mandible and Joint disc were found Some fibro blast cells were taken from the condyle Conclusion: The TMJs w ere induced pathologic changes in different degrees under various experimental v ariables The increasing +Gz exposure could lead to the heavier damage of Rat's TMJ
出处
《军医进修学院学报》
CAS
2003年第2期150-151,共2页
Academic Journal of Pla Postgraduate Medical School
基金
"九五"军队科研基金项目 ( 98M5 7)
"十五"军队科研基金项目 ( 0 1Q0 61)
关键词
颞下颌关节
加速度反应
超微结构
组织学
temporomandibular joint
acceleration
histology
ultrastructure
rats
