摘要
目的 :观察中药舒郁散治疗抑郁症的疗效及安全性 ,并与西药帕罗西汀进行对比研究。方法 :采用美国 1994年心理精神病学会的抑郁症诊断标准 ,对确诊为抑郁症的患者采用汉密尔顿抑郁量表 (HAMD) ,积分≥ 17分 ,临床表现综合评分 (CGI S)≥ 4 0的 6 5例患者纳入临床观察 ,随机分为中药舒郁散治疗组及西药帕罗西汀治疗组进行对比研究 ,观察治疗前后的汉密尔顿抑郁量表 ,临床表现综合评分 (CGI S)的积分变化来评定疗效 ;同时观察两组治疗后患者临床不良反应的发生率 ,以评定两种药物治疗的安全性。结果 :两组治疗前、后的自身积分变化比较差异有显著性意义 ,中医治疗组的有效率为 6 8 75 % ,西医治疗组的有效率为 78 78% ,两组间有效率的比较差异无显著性意义 ,西医治疗组有 36 4 %的患者出现副作用 ,中医治疗组有 12 5 %的患者出现副作用 ,两组间不良反应发生率的比较差异有显著性意义。结论 :舒郁散治疗抑郁症有效 ,虽然帕罗西汀比中药舒郁散治疗抑郁症有效率高 ,两组间统计差异无显著性意义 。
Objective:The aim of the present study was to observation the efficacy and safety on traditional Chinese medicine Shuyusan on treatment depression patients This study will be compared with Paroxetine. Methods:65 patients who met the depression diagnostic criteria of A merican Psychiatric Association 1994 of major depression or bipolar disorder, wi th a total Hamilton Depression Rating Scale (HAMD) mark ≥17 items and Clinical Global Impressions Severity of Illness scale (CGI S) ≥4 0 were entered the s tudy The 33 of total patients were treated with Paroxetine and the other patie nts treated with Shuyusan for 42 days The efficacy was assessed by Hamilton As sess Depression mark, Clinical Global Impressions Severity of Illness scale (CG I S) mark At the same time it access to treat safely by happening rate of sid e effect. Results: There was significant difference in the two g roups, comparison the marks before and after treatment The efficacy rate of Pa roxetine group was 78 78%, the traditional Chinese medicine group was 68 75% Comparison with the efficacy rate between the two groups, there was no signific ant difference The side effect in Paroxetine group was 36 4% and 12 5% in th e traditional Chinese Medicine group Comparison with the happening rate of sid e effect between the two groups, there was significant difference. Concl usion: Shuyusan is efficacious in treatment depression Although Paroxe tine have higher efficacious rate than traditional Chinese medicine Shuyusan, th ere was no significant difference between the two groups But Shuyusan is more safety than Paroxetine in treatment depression
出处
《军医进修学院学报》
CAS
2003年第2期135-137,共3页
Academic Journal of Pla Postgraduate Medical School
关键词
抑郁症
中医治疗
中药
舒郁散
depression
paroxetine
pharmacotherapy,Tcm
