摘要
目的 :观察 30例体外循环麻醉手术患者血清中TNF -α、IL - 6、IL - 8、IL - 1 0的动态变化。方法 :分两组 ,A组 :1 5例先心病体外循环麻醉手术患者 ;B组 :1 5例后心病体外循环麻醉手术患者 ,采用ELISA法和放射免疫法检测血清中细胞因子的浓度。结果 :30例心脏病体外循环麻醉手术患者 ,在心肺转流前开始 ,TNF -α、IL - 6、IL - 8、IL - 1 0均有显著升高 ,A、B两组的TNF -α值分别由 (3 .94± 1 .55)和 (4.89± 2 .60 )升高至 (2 1 .85± 9.93)和 (52 .36± 1 4 .79) ;A组的IL - 6由 (0 .1 6± 0 .0 5)升高(0 .95± 0 .48) ;IL - 8由 (0 .60± 0 .0 7)升高至 (1 .2 4± 0 .0 9) ;A、B两组的IL - 1 0分别由 (51 .2 1± 1 0 .60 )和 (78.50± 62 .40 )升高至(52 9.40± 2 57.1 2 )和 (1 1 51 .1 2± 62 4 .0 0 ) (P <0 .0 1 ) ,TNF -α、IL - 1 0先心病与后心病对比有显著差异。结论 :体外循环麻醉手术患者围手术期 ,TNF -α、IL - 6、IL - 8、IL - 1 0的表达提示免疫系统功能紊乱 ,且与术后感染、心功能不全有关 。
Objective: To observe the variations in serum tumor necrosis factor alpha(TNF-α), interleukin-6(IL-6), interleukin-8(IL- 8) and interleukin-10(IL-10) in 30 patients undergoing anesthesia during cardiopulmonary bypsss. Methods: Thirty patients underwent anesthesia were observed with quantitative ELISA and radioactivity immunoassay during cardiopulmonary bypass(CPB). Results:The serum levels of TNF-α,IL-6,IL-8 and IL- 10 in 30 patients with heart operation were significantly increased before CPB ( P <0.01).TNF-α increased from (3.94± 1.55 ) to (21.85±9.93), IL- 6 increased from (0.16±0.05) to (0.95±0.48), IL-8 increased from (0.60± 0.07) to (1.24±0.09) and IL- 10 increased from (51.21±10.6) to (529.40±257.12). However, the serum levels of TNF -α and IL-10 with rheumatic heart disease were increased more than those of the patients with congenital heart disease ( P <0.01).Conclusion: The expression of TNF-α, IL-6,IL-8 and IL-10 in patients undergoing anesthesia during CPB indicates there is immune system disorder and maybe related with infection and heart failure.We must pay much attention to this problem.
出处
《西北国防医学杂志》
CAS
2003年第3期191-193,共3页
Medical Journal of National Defending Forces in Northwest China
