摘要
目的 探讨急性胰腺炎(acute pancreatitis,AP)患者外周血细胞因子的变化与APACHEⅡ评分的相关性。方法 化学发光法检测66例AP患者外周血IL-6、IL-8、TNF-α的变化及按APACHEⅡ评分,评估病情的严重程度。结果 AP患者中IL-6、IL-8、TNF-α的含量明显增高,与正常对照组比较差异非常显著(P<0.01),细胞因子的变化与病情严重程度相一致,与APACHEⅡ评分呈正相关。结论IL-6、IL-8、TNF-α和APACHEⅡ评分能够作为评价AP严重程度的客观指标。
Objective To investigate the correlation between cytokines and APACHE I scoring in acute pancreatitis (AP). Methods Interleukin-6, 8(IL-6, IL-8) and tumor necrosis factor(TNF) were detected in peripheral blood of 66 patients with AP and 10 health persons. The results were compared with the acute physiology and chronic health evaluation (APACHE I ) scores. Results The levels of IL-6, IL-8 and TNF-a in plasma of AP patients were significantly higher than those in control group (P < 0. 01) , and the changes were correlated with the clinical symptoms and APACHE I scores. Conclusions Based on these results, it would seem logical to use both APACHE I score and IL-6, 8 and TNF-a percentages to assess the severity of AP.
出处
《胰腺病学》
2003年第2期81-83,共3页
Chinese JOurnal of Pancreatology
