摘要
目的 初步探讨中成药泽桂癃爽胶囊 (主要成分为泽兰、皂角刺、肉桂 )治疗良性前列腺增生 (BPH)的疗效和作用机理。 方法 2 0例BPH患者 ,随机分成药物组和对照组各 10例 ,询问病史 ,填写国际前列腺症状评分表 (IPSS) ,进行直肠指诊、B超、尿流率等检查。药物组患者服泽桂癃爽胶囊每天 3次 ,每次 2粒 ,1个月后再次填写IPSS并重复上述检查 ,于停药后次日手术切除前列腺 ;对照组患者直接切除前列腺。手术标本明确BPH病理诊断后进行免疫组化染色 ,分别比较两组标本碱性成纤维生长因子 (bFGF)、血小板衍化生长因子 (PDGF)和雄激素受体 (AR)抗原表达程度。 结果 药物组患者服药后下尿路症状改善 ,平均IPSS评分降低 11.2 % ,平均前列腺体积缩小 16 .7% ,平均最大尿流率提高 35 .6 %。与对照组比较 ,药物组bFGF表达减弱 (P <0 .0 1) ,PDGF和AR表达无明显变化。 结论 泽桂癃爽胶囊能改善BPH症状 ,缩小前列腺体积 ,提高最大尿流率 ,作用机理与抑制bFGF表达有关。
Objective To conduct a preliminary study on the efficacy and mechanism of Chinese traditional medicine Zeguilongshuang capsule for benign prostatic hyperplasia (BPH). Methods 20 patients with BPH were randomized into treatment group and control group (10 patients in each group).The medical history,International Prostate Symptom Score (IPSS),digital rectal examination,ultrasonography and uroflowmetry were done at the baseline.Patients in the treatment group used two Zeguilongshuang capsules three times per day for one month with repeated IPSS and above-mentioned examinations. They underwent prostatectomy on the next day when the treatment was completed.Patients in the control group received prostatectomy directly. After the pathological diagnosis of BPH was made,the expression of basic fibroblast growth factor (bFGF),platelet-derived growth factor (PDGF) and androgen receptor (AR) in the BPH tissue were assessed by immunohistochemistry. Results Patients in the treatment group reported improvement of low urinary tract symptoms, the mean IPSS decreased by 11.2%,the mean volume of the prostate reduced by 16.7%,and the mean maximum flow rate increased by 35.6%.Compared with the control group,the expression of bFGF in BPH tissue was down regulated ( P <0.01).There were no significant changes of the expression of PDGF and AR. Conclusions Zeguilongshuang capsule could improve the symptoms of BPH, reduce the volume of the prostate and increase the maximum flow rate. This effect maybe due to the inhibition of bFGF expression.Further study was needed.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2003年第6期388-390,共3页
Chinese Journal of Urology
