摘要
目的 研究老年急性脑血管病患者血浆内皮素 (ET)含量的变化 ,并探讨其在病理过程中的作用。 方法 用放射免疫技术测定急性脑梗死组 6 0例 ,急性脑出血组 4 9例 ,冠状动脉粥样硬化性心脏病 (冠心病 )组 5 7例和对照组 6 0例的血浆ET水平 ,进行统计学分析。 结果 急性脑梗死组、急性脑出血组、冠心病组血浆ET水平均较对照组明显升高 (P <0 .0 5 ) ,急性脑梗死组及脑出血组的血浆ET水平较冠心病组升高更明显 (P <0 .0 5 ) ,但脑梗死组与脑出血组的ET水平无明显差异 (P >0 .0 5 )。 结论 老年急性脑血管病患者血浆ET水平明显升高 。
Objective To study the plasma endothelin(ET) level in old patients with acute cerebrovascular disease and the role of ET in the pathogenesis of acute cerebrovascular disease. Methods The plasma ET level of 109 patient with acute cerebrovascular disease that contained acute cerebral infarction (60 cases) and acute intracerebral hemorrhage (49 cases), 57 patients with coronary atherosclerotic heart disease and 60 persons of control group were detected by radioimmunoassay. Results The level of plasma ET in acute cerebrovascular disease group and coronary heart disease group was significantly higher than that in control group(P<0.05). The level of plasma ET in acute cerebral infarction and acute intracerebral hemorrhage was significantly higher than that in coronary heart disease group (P<0.05). However, there was no significant difference between acute cerebral infarction group and acute cerebral hemorrhage group(P>0.05). Conclusion The remarkably elevated level of plasma ET in old patients with acute cerebrovascular disease indicates that plasma ET plays an important role in the development of brain injury in acute cerebrovascular disease, and promotes the initiation and progression of the disease.
出处
《现代实用医学》
2003年第6期347-348,共2页
Modern Practical Medicine
