摘要
研究氟氧头孢在老年腹腔感染患者体内的药物动力学 ,并与健康志愿者比较。 6例健康志愿者和 6例老年腹腔感染患者分别静脉滴注氟氧头孢钠 1g,采用 HPL C法测定血浆和尿中药物浓度 ,主要药物动力学参数分别为t1 / 2 -(1.18± 0 .2 0 ) h和 (1.93± 0 .3 1) h,Cls-(16.63± 1.73 ) L/h和 (10 .95± 2 .65 ) L/h,AUC-(63 .47± 4.5 7) h·μg·ml-1和 (99.45± 2 0 .2 3 ) h·μg· ml-1。氟氧头孢药 -时曲线符合二室开放模型 ,主要代谢方式是经肾脏原形排出。与健康志愿者相比 。
The pharmacokinetics of flomoxef in 6 healthy volunteers and 6 elder patients with abdominal infection diseases after infusion of 1 g flomoxef sodium injection were studied. Flomoxef concentrations in plasma and urine were determined by HPLC. The main pharmacokinetic parameters of flomoxef in healthy volunteers and elder patients were t 1/2 -(1.18±0.20) h and (1.93±0.31) h, Cls -(16.63± 1.73) L·h -1 and (10.95±2.65) L·h -1 , AUC -(63.47±4.57) h·μg·ml -1 and (99.45±20.23) h·μg·ml -1 ,respectively. Drug concentrations time profile of flomoxef was fitted to two compartment open pharmacokinetic model. Flomoxef was mainly excreted in unchanged form through kidney. Elder patients had prolonged t 1/2 , lowered Cls and elevated AUC in comparison with healthy volunteers. The results showed that flomoxef was metabolized and eliminated more slowly in the former than in the latter.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2003年第6期285-287,共3页
Chinese Journal of Pharmaceuticals
