摘要
目的 合成抗偏头痛药盐酸洛美利嗪。方法 以 2 ,3,4 三甲氧基苯甲醛为原料与双 (4 氟苯基 )甲基哌嗪通过Leuckart Wallach反应生成盐酸洛美利嗪。结果 反应经过改进 ,收率达到 5 6 .9%。所得产品结构经IR 1H NMR ,MS ,元素分析确证。结论 本工艺路线方法简单 ,原料易得 ,宜工业化生产。
OBJECTIVE To synthesize Lomerizine hydrochloride,a new drug for the treatment of antimigraine. METHOD Lomerizine hydrochloride was synthesized via Leuckart Wallach reaction.RESULTS The reaction was modified and improved,the yield was 56.9%.The structure of title compound was confirmed by IR, 1H NMR,MS and elemental analysis data.CONCLUSION The process can be easily controlled and is suitable for a scale production.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2003年第3期186-187,共2页
Chinese Journal of Modern Applied Pharmacy
