摘要
目的:探讨内皮素—1在EH发生中的作用以及氯沙坦干预前、后EH患者内皮素—1水平的变化。方法:76例高血压患者眼用氯沙坦6周(剂量50～100mg/d),部分患者加用双氢氯噻嗪(12.5mg,2次/d),观察氯沙坦治疗前、后血压和血浆内皮素—1的变化。结果:EH组与对照组血浆内皮素—1水平分别为89.13±29.17ng/L、60.13±10.23ng/L,前者显著升高(P<0.05),高血压Ⅲ级者的ET-1水平显著高于高血压Ⅱ级的(P<0.05)。氯沙坦治疗前、后内皮素—1水平分别为89.13±29.17ng/L、65.32±7.19ng/L,治疗后的显著降低(P<0.01)。氯沙坦治疗前收缩压和舒张庄分别为168.34±12.92、112.46±6.09mmHg,治疗后分别为125.71±20.05、80.15±5.11mmHg,均较治疗前明显降低(P<0.01)。结论:内皮素—1在高血压的形成和维持中起者重要的作用,氯沙坦在有效降压时,可以降低血浆内皮素—1水平。
Objective: To study the effect of endothelin-1 on occurrence of essential hypertension (EH) and the change of the plasma endothelin-1 in EH patients before and after the treatment with losartan. Methods: A total of 76 patients with EH were treated with losartan. Forty-two health people were selected as controlled group. The dose of losartan was 50 - 100 mg per day and dose of some patients was added hydrochlorothiazide 12. 5 mg 2 times per day. The levels of plasma endothelin\|1 and blood pressure were measured before and after the treatment of losartan. Results: The plasma endothelin-1 level of EH patients was significantly higher than that of controlled group(89. 13 ± 29.17 ng/L vs 60. 13±10. 23 mg/L, P<0. 05). The endothelin-1 level of EH patients stage Ⅲ was higher than that of EH patients stage Ⅱ (118. 04±35. 06 vs 80. 85 ± 15. 88.P<0. 05). After the treatment with losartan, the endothelin-1 levels were decreased significantly (89. 13± 29. 17 ng/L vs 65. 3±7. 19 ng/L.P<0. 01). The SBP and DBF were significant lower after the treatment with losartan than those before the treatment (125. 71±20. 05 vs 168. 34±12. 92 mmHg, 80. 15± 5.11 vs 112. 46±6.09 mmHg, P<0. 01). Conclusion: Endothelin-1 may play an important role in the initiation and maintenances of EH. The treatment with losartan can decrease not only the blood pressure but also the level of plasma endothlin-1 in EH patients.
出处
《心血管康复医学杂志》
CAS
2003年第3期235-238,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
