摘要
目的设计、合成硫色满酮 3位Mannich碱类化合物 ,并对其抗真菌活性进行初步评价。方法以对氟苯硫酚为原料 ,经多步反应合成目标化合物 ,并测定目标化合物的抗真菌活性。结果共合成了 10个未见文献报道的新化合物 ,经红外光谱、核磁共振氢谱及元素分析确证了其结构。其中化合物 3对大部分供试真菌活性强于或相当于对照品克霉唑。结论硫色满酮 3位取代Mannich碱具有较强的抗真菌活性。
Aim To design and synthesize the Mannich bases of thiochromanones,and to study their antifungal activity. Methods The target compounds were synthesized from the p -fluorothiophenols,and tested for their antifungal activities in vitro . Results Ten new compounds were synthesized.The structures of these compounds were confirmed by IR, 1H-NMR and elemental analysis.The compound 3 gave excellent antifungal activity and its MIC value was below or equal to that of the control. Conclusion The Mannich bases of thiochromanones have good antifungal activity.
出处
《中国药物化学杂志》
CAS
CSCD
2003年第3期134-137,共4页
Chinese Journal of Medicinal Chemistry
基金
辽宁省自然科学基金项目 (2 0 0 2 2 0 5 3)
沈阳市高科技创业种子基金项目 (0 2Z0 10 0 5 5 )
关键词
药物化学
制备
化学合成
硫色满酮
MANNICH碱
抗真菌活性
medicinal chemistry
preparation
chemical synthesis
thiochromanones
Mannich bases
antifungal activity
