摘要
目的 :探讨清利冲剂治疗急性肾盂肾炎的治疗作用及机理。方法 :用膀胱内注射大肠杆菌 ,一侧输尿管暂时结扎的方法建立大鼠急性逆行肾盂肾炎动物模型 ,观察清利冲剂治疗后肾脏大体形态 ,细菌学和病理学变化。结果 :治疗后 ,治疗各组大鼠的患肾形态和病理明显改善 ,肾组织和尿细菌培养阳性率明显减少 ,尤以清利冲剂Ⅱ组明显。结论 :清利冲剂能有效地抑制患鼠尿液和左肾组织中细菌的生长 。
Objective:To evaluate therapeutic effect and mechanism of Qingli granule on acute pyelonephritis.Methods:Rat models of acute pyelonphritis were established by injecting Escherichiacoli into urinary bladder and ligating unilateral ureter temporarily.To oberse the changes of bacteriology and pathology in kidneys after treatment with Qingli granule,and compare with San Jin tablet.Results:After treatment,the injuries and pathological changes in kidneys were obviously improved in all treated groups,the positive rate of bacteria culture in renal tissue and urine was reduced obviously,especially in the Qingli granule Ⅱ group.Conclusion:Qingli granule can effectively inhibit bacterial growing in urine and improve the pathological changes of kidneys in acute pyelonephritis.
出处
《中国中西医结合肾病杂志》
2003年第6期330-331,共2页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
山东省中医管理局基金资助项目 (No .19940 0 2 )
