摘要
目的 :通过观察当归影响实验性高脂致家兔主动脉粥样硬化的效果 ,探讨当归抗动脉粥样硬化作用的机制。方法 :取健康家兔随机分正常对照组 (普通饲料喂养 ) ;高脂组 (高脂饲料喂养 )和当归治疗组 (高脂饲料加当归注射液 )。喂养 10周末处死动物 ,检测主动脉AS斑块面积 ,透射电镜观察主动脉超微结构的变化 ,并速将主动脉条置入不同乙酰胆碱 (Ach)浓度中 ,用Griess反应法检测一氧化氮 (NO)含量。结果 :当归可显著减小粥样斑块面积 ,抑制动脉壁泡沫细胞形成 ,并增加主动脉NO的生成含量。结论 :当归可拮抗高脂导致的动脉粥样硬化的形成 ,这种作用可能与它保护内皮细胞、减少泡沫细胞形成、影响NO生成有关。
To study the antiatherosclerosis effect of angelica and its mechanism. Methods: Healthy rabbits were divided randomly into normal control group (common forage), high lipid model group (high lipid forage) and angelica group (high lipid forage adding angelica injection). At the end of 10 th week, aorta were obtained from the rabbits. Aorta were prepared for measurement of plaque area, observation of aorta ultrastructure and detection of aorta NO production induced by Ach in Griess reaction. Results: Angelica could decrease the plaque area significantly, inhibit the formation of foam cell in artery and increase the release of NO in aorta. Conclusion: Angelica can inhibit atherogenesis, which maybe relate to its effects of protecting ECs, decreasing the formation of foam cell and influencing NO synthesis.
出处
《湖北中医学院学报》
2003年第2期29-30,共2页
Journal of Hubei College of Traditional Chinese Medicine
关键词
当归
高脂
家兔
主动脉粥样硬化
乙酰胆碱
一氧化氮
Angelica Endothelial cell Nitric oxide Acetylcholine Atherosclerosis Aorta
