摘要
目的 :观察紫杉醇卡铂化疗联合放射治疗局部晚期非小细胞肺癌 (NSCL C)的近期疗效及毒副反应。方法 :3 2例局部晚期NSCLC患者 ,采用紫杉醇加卡铂联合化疗 (紫杉醇 13 5 mg/m2 ,静滴 ,第 1天 ;卡铂 3 0 0 mg/m2 ,静滴 ,第 2天 ,每 2 1天为 1周期 ,共 2～ 3周期 ) ,并与放射治疗 (常规分割 ,DT62～ 68Gy/3 1～ 3 4次 )交替进行 (夹心疗法 )。结果 :全组 CR2例 ,PR16例 ,总有效率 (CR+ PR) 5 6.3 % ,无严重毒副反应。平均生存期 14 .5月。结论 :紫杉醇卡铂化疗联合放射治疗局部晚期 NSCLC能提高近期疗效 ,远处转移有降低趋势 ,且毒副作用可耐受 。
Objective:To observe the short term efficacy and toxic effects of paclitaxel combined with carboplatin and radiotherapy in patients with local advanced non small cell lung cancer(NSCLC).Methods:Thirty two patients with NSCLC stage Ⅲ A or Ⅲ B were treated with paclitaxel(135 mg/m 2)on day 1 and carboplatin (300 mg/m 2)on day 2.Treatment was repeated every 3 weeks for a total of 2 3 circles.The conventional radiotherapy was interposed between the two circles.Results:Complete responses were seen in 2(6.3%),partial responses in 16(50%)and no change in 14(43.7%)patients.The mean duration of survival was 14.5 months.There were no serious toxic effects.Conclusion:since this combination therapy can improve the short term efficacy and have acceptable toxicity in patients with local advanced NSCLC,it deserves further evaluation.
出处
《广东医学院学报》
2002年第6期424-425,共2页
Journal of Guangdong Medical College
