摘要
将妊娠大鼠随机分为5组,即敌枯双1mg/kg·d^(-1)(阳性对照组)、空白乳剂(阴性对照组)、萘实验组1000mg/kg·d^(-1)、600mg/kg·d^(-1)和60mg/kg·d^(-1),分别在怀孕第6～15d经灌胃给药。实验结果:萘为1000mg/kg·d^(-1)和600mg/kg·d^(-1)剂量组的母鼠和仔鼠均体重减轻,影响仔鼠的发育,某些骨骼发生骨化迟缓(胸骨和枕骨)。在1000mg/kg·d^(-1)组早期吸收胎和死胎发生率增加,但未发现畸形仔鼠。60mg/kg·d^(-1)组和阴性对照组经统计学处理无显著性差异,母鼠和仔鼠均无任何影响。阳性对照组则有明显的致畸作用。认为萘对大鼠不是一种致畸原。
Pregnant SD rats were divided into 5 groups randomly, ie N, N'-methylene-Bis (2-Amino 1, 2, 4-Thiadiazole) 1mg/kg·d^(-1) (positive control), blank emulsion (negative control), and naphthalene 1000mg/kg·d^(-1),600mg/kg·d^(-1) & 60mg/kg·d^(-1),and were administered by gastric intubation daily within 6 to 15d of the pregnancy.
The results of experiments demonstrated that naphthalene dose at 600mg/kg·d^(-1) & 1000mg/kg·d^(-1) both maternal body weight gain &embryo fetal development were depressed, and ossification of some parts of the skeletal districts (Sternum & occipital bone)were retarded. At 1000mg/kg·d^(-1) increased embryo absorption and death rate were found, but no malformed fetus. There were not any statistical difference between the naphthalene 60mg/kg·d^(-1) group & the negative control group, neither the dam nor the fetuses were affected. Pregnant rats of positive control group showed obvious teratogenic effects.
It may be concluded that naphthalene is not a teratogen of rat.
出处
《安徽医科大学学报》
CAS
1989年第1期16-19,共4页
Acta Universitatis Medicinalis Anhui
关键词
萘
致畸胎物
妊娠
中毒
大鼠
pregnancy
animal, laboratory
teratogens
naphthalenes
poisoning
