摘要
目的 :了解格拉司琼与恩丹西酮的费用 -效果比。方法 :对36例接受顺铂化疗的患者 ,采用随机自身对照的方法 ,比较国产格拉司琼与恩丹西酮的止吐效果和毒性 ,并进行费用 -效果分析。结果 :格拉司琼能有效预防顺铂所致的恶心、呕吐 ,其止吐效果与恩丹西酮相似。两药防治恶心平均有效率分别为75 9 %和77 8 % ;两药止吐平均有效率分别为79 7 %和75 0% ,疗效无统计学差异 ,毒副作用小。格拉司琼费用 -效果比优于恩丹西酮。结论 :盐酸格拉司琼为肿瘤化疗安全、有效、经济的止吐药物之一 ,值得推广应用。
OBJECTIVE:To compare the cost-effective ratios between Granisetron and Ondansetron in the prevention of Cisplatin-induced nausea and vomiting.METHODS:In a randomized auto-controlled design,36patients receiving chemotherapy with Cisplatin were divided into2groups to compare the antiemetic effects and toxicity between Granisetron and Ondansetron and to carry out cost-effectiveness analysis.RESULTS:Granisetron could effectively prevent Cisplatin-induced nausea and vomiting and its antiemetic effect was comparable to that of Ondansetron.The average effective rates in preventing nausea and vomiting of Granisetron and Ondansetron were75.9%,77.8%and79.7%,75.0%respectively,and there were no significant differences between two drugs.The toxic reactions of Granisetron were slight.In cost-effectiveness analysis,Granisetron was better than Ondansetron.CONCLUSION:Granisetron is a safe,effective,economical antiemotic in chemotherapy of cancers.It is worth popularizing the application.
出处
《中国药房》
CAS
CSCD
2003年第6期344-346,共3页
China Pharmacy
