摘要
目的 观察丹参对自发性高血压大鼠左室肥厚的作用。方法 18只 8周龄的自发性高血压大鼠随机分成 3组 :一组于 8周处死 ,另两组分别经腹腔注射丹参和蒸馏水 (1g/kg·d) ,共 10周。测量大鼠尾动脉收缩压 (SBP)及左心室重量指数 (LVMI)。应用HE、VG染色 ,结合计算机图像分析技术 ,检测心肌细胞的直径 (TDM)、面积 (CA)、心肌组织胶原体积比例 (CVF)、血管周围胶原面积和管腔面积比例 (PVCA)。结果 与 8周龄的自发性高血压大鼠相比 ,18周龄大鼠的SBP、LVMI、心肌细胞的直径、面积、CVF、PVCA显著增加 (P <0 0 1) ,丹参治疗组大鼠反映左室肥厚的各项指标上升不明显 (P >0 0 5 ) ,但收缩压仍显著升高 (P <0 0 1)。结论 长期应用丹参治疗可预防自发性高血压大鼠左室肥厚的形成。
Objective To observe the effect of Salvia Miltiorrhiza Bge (SMB) on preventing left ventricular hypertrophy(LVH)in spontaneously hypertensive rats(SHR). Methods Eighteen SHRs of 8 weeks old were divided into three groups at random. SMB and distilled water(1 g/kg·d)were injected intraperitoneally in two groups for 10 weeks. Systolic blood pressure(SBP)and left ventricular mass index(LVMI)were measured. HE and VG staining combined with computed morphometry were employed to evaluate the cardiomyocyte size, diameter, the collagen volume fraction(CVF),perivascular circumferential area(PVCA) in the left ventricular tissue. Results Compared with 8-week-old rats, the SBP, LVMI, cardiomyocyte size and diameter, CVF, PCVA increased markedly in SHRs of 18 wks old. Treated with SMB, the LVH was significantly prevented whereas SBP changed slightly. Conclusion Chronic treatment with SMB inhibit the development of LVH in SHR.
出处
《高血压杂志》
CAS
CSCD
2003年第3期257-259,T003,共4页
Chinese Journal of Hypertension
基金
湖北省自然科学基金资助课题 (2 0 0 0J0 64)
关键词
自发性高血压大鼠
左心室肥厚
丹参
spontaneously hypertensive rats
left ventricular hypertrophy
salvia miltiorrhiza bge
