摘要
目的 在自发性高血压大鼠 (spontaneouslyhypertensiverat,SHR)上 ,评价盐酸埃他卡林 (Iptakalimhydrochlo ride,Ipt)对高血压血管重构的实验治疗学作用。 方法 2 1只 12周龄SHR随机分为 3组 :Ipt3mg/kg治疗组 ,赖诺普利 (lisinopril,Lis) 12mg/kg治疗组和空白对照组。另设同月龄正常血压Wistar大鼠为正常对照组。大鼠igIpt、Lis或蒸馏水 10ml/kg ,每日 1次 ,连续 4周 ,观察药物对高血压血管重构的影响。 结果 实验期 4周内 ,SHR对照组血压和心率持续性进行性增高。其主动脉中层壁显著增厚 ,中层壁厚与内径的比值 (M/L)也显著增大 ;肠系膜动脉的中层壁显著增厚 ,内径显著变小 ,二者的比值显著增大 ,表明高血压时动脉的结构发生了重构。Ipt能有效控制SHR的血压 ,降压效果确切 ,且可抑制SHR心率加快的趋势 ;Ipt治疗可阻止肠系膜动脉和主动脉的结构重构。相同实验条件下 ,Lis也均能有效控制SHR的血压 ,降压效果确切 ,对心率无明显影响 ;Lis治疗也可阻止肠系膜动脉和主动脉的结构重构。结论 Ipt能有效地控制SHR的血压 ,可以阻止高血压血管结构重构。
Objective To study the experimental therapeutic effects of iptakalim hydrochloride(Ipt) on vascular remodeling in spontaneously hypertensive rats(SHR). Methods SHR at the age of 3 month old were treated ig with lisinopril 12 mg/kg·d -1 or Ipt 3 mg/kg·d -1 , once a day for 4 weeks. Normotensive rats(NTR) were used as normal control. The effects of Ipt on hypertensive vascular remodeling were investigated using light microscope. Results Systolic blood pressure(SBP) and heart rate(HR) of the untreated SHR were increased progressively with age. The media thickness and ratio of media thickness to lumen diameter of aorta and mesenteric arteries in untreated SHR were increased. Ipt 3 mg/kg·d -1 decreases SBP and inhibit the tendency of increasing HR. The remodeling of aorta and mesenteric arteries in SHR reversed by Ipt. Lisinopril 12 mg/kg·d -1 decrease SBP with no effects on HR. The remodeling of aorta and mesenteric arteries could be reversed by lisinopril. Conclusion Ipt decreased SBP and partially reversed the remodeling of blood vessels in SHR.
出处
《高血压杂志》
CSCD
2003年第3期248-250,共3页
Chinese Journal of Hypertension
基金
国家新药研究与发展重点项目
№ 9690 1 0 1 0 1
