摘要
目的 :探讨多囊卵巢综合征 (PCOS)患者血清肿瘤坏死因子 α(TNF α)与胰岛素抵抗的关系。方法 :采用放射免疫法检测 30例PCOS患者及 35例正常对照组血清TNF α、黄体生成激素 (LH) /卵泡刺激素 (FSH)、睾酮 (T)及空腹胰岛素 ,用氧化酶法检测血浆葡萄糖浓度。结果 :PCOS组血清TNF α、LH/FSH、T、胰岛素抵抗指数 (HOMA IR)均显著高于对照组 (P <0 0 5 ) ;血清TNF α与HOMA IR、LH/FSH、T呈显著正相关。结论 :TNF α可能促进PCOS胰岛素抵抗的发生 ,两方面因素相互作用加重了PCOS的病理生理改变。
Objective:To investigate the relationship between tumor necrosis factor-α(TNF-α) and insulin resistance in polycystic ovary syndrome.Methods:Blood samples were collected from 30 patients with PCOS and another 35 healthy women as contents serum TNF-α?LH/FSH?testosterone (T) and fasting insulin were determined by radioimmunoassay.Plasma glucose was examined by oxidase test.Results:Serum TNF-α?LH/FSH,T levels and insulin resistance index(HOMA-IR) in PCOS patients were significant higher than those in control group( P <0.05).TNF-α level was positively related with HOMA-IR, LH/FSH, and T.Conclusions:It was suggested that TNF-α accelerate insulin resistance.The interaction between them aggravate the development of pathophysiology in PCOS.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2003年第3期167-168,共2页
Journal of Practical Obstetrics and Gynecology
基金
国家自然科学基金资助 (No :30 1 0 0 2 0 0 )
