摘要
目的 探讨老年人血清褪黑素 (松果腺主要在夜间分泌的一种吲哚胺类激素 )水平变化。方法 用放射免疫法检测了 14 4例山东大学人 (31～ 110岁 )夜间 (0 2 :0 0 )及白天 (0 8:0 0 )血清褪黑素水平。结果 夜间血清褪黑素水平随着年龄增长呈下降趋势 ,与成年人组比较 70岁组和 >80岁组的褪黑素水平明显降低 (P <0 .0 1) ;女性的褪黑素水平略高于男性 (P <0 .0 5 ) ;健康老年人与老年患者 (主要为心血管系统疾病 )比较褪黑素水平差异无显著性意义(P >0 .0 5 ) ,年龄、性别和健康状况对白天血清褪黑素水平无明显影响。结论 年龄与性别是影响老年人夜间血清褪黑素水平的主要因素 ,研究结果未能显示健康状况对老年人血清褪黑素水平的影响。
Objective To investigate serum melatonin (the hormone produced by pineal gland during the dark phase of circadian cycle) variations in Chinese elders.Method RIA was used to determine night(02:00) and morning(08:00) serum melatonin concentrations in 144 Chinese (31～110 years old).Results Night ( 02:00) serum melatonin levels showed decrease with aging and melatonin levels in 70s and >80s groups were significantly lower than that in <60s (P<0.01). Women had higher night serum melatonin levels than men had(P< 0.05).There were no significant differences(P>0.05)between healthy elders and patients (suffered mainly from cardiovascular diseases). Morning (08:00) serum melatonin levels showed no significant differences between different age, gender and healthy condition groups.Conclusion The results showed that both age and gender had significant influences on night (02:00) serum melatonin level,while failed to show any significant difference between healthy elders and patients.
出处
《中华老年心脑血管病杂志》
CAS
2003年第3期156-158,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
