摘要
目的 :研究牛奶中雌激素样物质对男性生殖系统的影响。 方法 :利用世界五大洲肿瘤发病数据库和联合国粮农组织 (FAO)数据库 ,对 42个国家 (地区 )前列腺癌和睾丸癌发病率 ( 1988～ 1992 )与相应的食物消费量资料 ( 1961～ 1990 )进行相关分析 ;根据美国食品药品管理局 (FDA)标准 ,选用Wistar大鼠 ,进行两代繁殖实验 ,主要研究牛奶中雌激素化合物对生殖器官的影响。 结果 :在所分析的食物中 ,前列腺癌与牛奶消费量的关系最密切(r =0 .711) ,其次是肉类与咖啡 ;奶酪与 2 0～ 3 9岁的睾丸癌标化发病率关系最密切 (r =0 .80 4) ,其次是动物性脂肪和牛奶 ;动物实验研究发现 ,大鼠经长期、大量地饮用牛奶后 ,未发现生殖器官明显减轻的现象。 结论
Objectives: To study the effects of estrogen-like products in milk on the male reproductive system. Methods: The incidence rates of testicular and prostatic cancers in 42 countries (regions), collected from the cancer incidence in five continent database (1988-1992), were correlated with the relative food consumption in these countries, which was provided by FAO database (1961-1990); two-generation reproduction test was taken by using Wistar rats according to FDA standard. Results: Among the food items examined, milk was most closely correlated (r= 0.711) with prostatic cancer incidence, followed by meat and coffee. As for testicular cancer, cheese was most closely correlated ( r= 0.804) with the incidences in ages of 20~39, followed by animal fat and milk. No significant decreases of reproductive organ weight were found after the rats had been fed a lot of milk for long time. Conclusions: The results suggest that further studies should be taken on the effects of estrogen-like products in milk on the male reproductive health. Natl J Androl,2003,9(3):186-190
出处
《中华男科学杂志》
CAS
CSCD
2003年第3期186-190,共5页
National Journal of Andrology
基金
江苏省生物工程重点开放实验室科研基金
扬州大学高级人才基金资助
关键词
牛奶
前列腺癌
睾丸癌
雌激素样物质
两代繁殖实验
Milk
Prostatic cancer
Testicular cancer
Estrogen-like product
Two-generation reproduction test
