摘要
［目的］观察沙培林(OK-４３２)及顺铂治疗恶性心包积液的近期疗效和耐受性。［方法］５６例中等及大量恶性心包积液患者心包穿刺置管引流后腔内随机分组注射，沙培林组(生理盐水２０ml＋OK-４３２２KE＋地塞米松１０mg／次)３０例，顺铂组(生理盐水４０ml＋顺铂５０mg～６０mg／次)２６例，腔内用药最多重复３次。［结果］沙培林组有效率为９３．３％。主要不良反应为发热；顺铂组有效率为６５．４％，主要不良反应为骨髓抑制及胃肠道反应，两组有效率及不良反应均有显著差异(P＜０．０５)。［结论］沙培林治疗恶性心包积液沙培林有效率高，不良反应小，患者耐受性好，值得临床推广应用。
To evaluate the short-term efficacy and the tolerance of OK-432and cisplatin in the treatment for malignant pericardial effusion.Fifty-six patients with severe and medium malignant pericardial effusion were randomly divided into two groups:OK-432group(n=30,OK-4322KE+dexamethasone10mg+normal saline20ml)and cisplatin group(n=26,cisplatin50mg～60mg+normal saline40ml).The injection into pericardial cavity were repeated no more than3times.The response rate was93.3%in OK-432group,the major side-effect of the regimen was fever;The response rate was65.4%in cisplatin group,the major side-effect of the regimen included neutropenia,nausea and vomiting.The response rate and the side-effect of two groups were significantly different(P<0.05).[Conclusion]OK-432is well tolerated and effective in the treatment of pericardial effusion.It is worth to spread in the clinical use.
出处
《肿瘤学杂志》
CAS
2003年第3期165-166,共2页
Journal of Chinese Oncology
关键词
心包积液
沙培林
顺铂
疗效
溶血性链球菌
pericardial effusion
OK-432
cisplatin
efficacy
hemolytic streptococcus
